Claus BachertRuby PawankarLuo ZhangChaweewan BunnagWytske J. FokkensDaniel L. HamilosOrathai JirapongsananurukRobert KernEli O. MeltzerJoaquim MullolRobert NaclerioRenata PilanChae Seo RheeHarumi SuzakiRichard VoegelsMichael BlaissUniversity Hospital of GhentNippon Medical SchoolBeijing Institute of OtorhinolaryngologyMahidol UniversityAcademic Medical Centre, University of AmsterdamMassachusetts General HospitalNorthwestern University Feinberg School of MedicineAllergy and Asthma Medical Group and Research CenterInstitut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPSUniversity of ChicagoUniversidade de Sao Paulo - USPSeoul National University Bundang HospitalShowa UniversityUniversity of Tennessee Health Science Center2018-11-092018-11-092014-01-01World Allergy Organization Journal. Vol.7, No.1 (2014)193945512-s2.0-84988965444https://repository.li.mahidol.ac.th/handle/20.500.14594/34109© 2014 Bachert et al. Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to different disease variants - further complicates our understanding and directions for the most appropriate targeted treatment strategies. Several International/national guidelines/position papers and/or consensus documents are available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and treatment options in both adults and children comprising pharmacotherapy, surgical interventions and more recent biological approaches. Finally, we have also highlighted the unmet needs that wait to be addressed through future research.Mahidol UniversityImmunology and MicrobiologyMedicineReviewSCOPUS10.1186/1939-4551-7-25