Shamim E.A.Kim M.S.Kang S.Y.Srivanitchapoom P.Jin S.H.Houdayer E.Diomi P.Thirugnanasambandam N.Kukke S.N.Matsuhashi M.Lamy J.C.Wu T.Meunier S.Hallett M.Mahidol University2024-10-312024-10-312024-12-01Clinical Neurophysiology Vol.168 (2024) , 63-7113882457https://repository.li.mahidol.ac.th/handle/20.500.14594/101835Objective: Because focal hand dystonia usually occurs in the over-learned stage, it would be valuable to know long-term motor learning characteristics and underlying pathophysiological features that might predispose to dystonia. Methods: We conducted a case-control exploratory study of 15 visits over 12 weeks in the non-affected hand of a 4-finger sequence of 8 key presses in eight patients with FHD compared with eight age- and sex-matched, healthy volunteers (HVs). We studied the behavioral data and the physiological changes of the brain, including motor cortical excitability and cortical oscillations. Results: There was no significant difference in the time to reach 100 % accuracy between FHD and HV during the 80-day follow-up period. There was a statistically significant difference in the accuracy of sequential finger movement tasks between patients with FHD compared with HVs over 12 weeks, but post-hoc analysis with multiple comparion correction did not show difference. There were no significant differences in recruitment curve changes and task-related power changes of alpha and beta bands. Conclusion: Over 12 weeks, FHD have motor learning capacity comparable to HVs and do not show pathophysiological abnormalities. Significance: Further studies would be valuable with more patients, more extended periods of practice, and more detailed electrophysiological explorations.NeuroscienceMedicineArticleSCOPUS10.1016/j.clinph.2024.09.0242-s2.0-8520729458518728952