Ornnicha ThanatvarakornSyozi NakashimaAlireza SadrTaweesak PrasansuttipornSuppason ThitthaweeratJunji TagamiTokyo Medical and Dental UniversityChiang Mai UniversityMahidol University2018-10-192018-10-192013-07-31Dental Materials Journal. Vol.32, No.4 (2013), 615-62118811361028745472-s2.0-84880993236https://repository.li.mahidol.ac.th/handle/20.500.14594/31673This study aimed to evaluate the ability of a newly developed calcium-phosphate desensitizer in dentin permeability reduction and its integration with dentin surface before and after immersion in artificial saliva (AS) under two different dentin surface characteristics; with or without the collagen exposure. Human dentin discs treated by EDTA to expose collagen fibrils or EDTA/NaOCl to expose plain dentin surface were subjected to a calcium-phosphate desensitizer (Teethmate Desensitizer; TMD), while non-desensitizer treatment served as control. TMD application showed the occlusion in dentinal tubules and reduction in dentin permeability up to 92%, regardless of dentin surface characteristics. After AS immersion, permeability reduction percent (PR%) significantly increased in EDTA/NaOCl pretreatment (p<0.05). Newly-formed crystallites were observed on desensitizer treated dentin and EDTA/NaOCl pretreatment control group, whereas the crystallites did not exist on EDTA pretreatment control group. Ultrasonication revealed the integration of the calcium-phosphate rich layer of desensitizer on dentin surface after AS immersion.Mahidol UniversityDentistryMaterials ScienceMedicineArticleSCOPUS10.4012/dmj.2013-073