Thichakorn JittawuttipokaRatiboot SallabhanPaiboon VattanaviboonMayuree FuangthongSkorn MongkolsukMahidol UniversityChulabhorn Research InstituteChulabhorn Graduate InstituteCenter of Excellence on Environmental Health2018-09-242018-09-242010-05-01Archives of Microbiology. Vol.192, No.5 (2010), 331-339030289332-s2.0-77952098034https://repository.li.mahidol.ac.th/handle/20.500.14594/28724Iron is essential in numerous cellular functions. Intracellular iron homeostasis must be maintained for cell survival and protection against iron's toxic effects. Here, we characterize the roles of Xanthomonas campestris pv. campestris (Xcc) fur, which encodes an iron sensor and a transcriptional regulator that acts in iron homeostasis, oxidative stress, and virulence. Herein, we isolated spontaneous Xcc fur mutants that had high intracellular iron concentrations due to constitutively high siderophore levels and increased expression of iron transport genes. These mutants also had reduced aerobic plating efficiency and resistance to peroxide killing. Moreover, one fur mutant was attenuated on a host plant, thus indicating that fur has important roles in the virulence of X. campestris pv. campestris. © 2010 Springer-Verlag.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyArticleSCOPUS10.1007/s00203-010-0558-8