N. J. WhiteS. LooareesuwanD. A. WarrellM. J. WarrellP. ChanthavanichD. BunnagT. HarinasutaMahidol University2018-10-122018-10-121983-01-01American Journal of Tropical Medicine and Hygiene. Vol.32, No.1 (1983), 1-5000296372-s2.0-0020674725https://repository.li.mahidol.ac.th/handle/20.500.14594/30478In cerebral malaria, the use of currently recommended doses of intravenous quinine may results in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.4269/ajtmh.1983.32.1