Juthamas JaroensukNicole StoesserMara L. LeimanisPodjanee JittamalaNicholas J. WhiteFrancois H. NostenRose McGreadyMahidol UniversityJohn Radcliffe HospitalNuffield Department of Clinical MedicineShoklo Malaria Research Unit2018-11-092018-11-092014-01-01American Journal of Tropical Medicine and Hygiene. Vol.90, No.4 (2014), 609-611000296372-s2.0-84898757143https://repository.li.mahidol.ac.th/handle/20.500.14594/34087Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.4269/ajtmh.13-0706