Ploy PattanakitsakulNalinee ChongviriyaphanSamart PakakasamaNopporn ApiwattanakulFaculty of Medicine, Ramathibodi Hospital, Mahidol University2020-11-182020-11-182020-10-02BMC Research Notes. Vol.13, No.1 (2020)175605002-s2.0-85092384378https://repository.li.mahidol.ac.th/handle/20.500.14594/59870© 2020 The Author(s). Objective: Vitamin A is involved in maintenance of gut mucosal integrity and normal immune function. However, it is unclear whether these functions of vitamin A have any beneficial effects in patients undergoing hematopoietic stem cell transplantation (HSCT). In this study, we aimed to examine the potential protective effect of vitamin A supplementation on gastrointestinal (GI) mucosal integrity in HSCT recipients using plasma citrulline as a surrogate marker of intestinal integrity. Results: We performed a quasi-randomized trial in 30 pediatric patients undergoing HSCT. Half (n = 15) of the patients received a single high dose of vitamin A (200,000 IU) before the conditioning regimen was given, and half (n = 15) did not. Clinical data of patients who developed post-Transplant complications were recorded for 60 days after HSCT. There were no significant differences in mean plasma citrulline levels on day 7 after HSCT between the treatment and control groups (5.8 vs. 5.9 μmol/L, respectively). The incidence of mucositis and other complications were not different between the two groups within 60 days of HSCT. Vitamin A supplementation prior to HSCT in pediatric patients had no clinical benefit in protecting GI mucosal integrity.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1186/s13104-020-05307-8