La-Ongthong K.Sawekteeratana N.Klaysuk J.Soorukram D.Leowanawat P.Reutrakul V.Krobthong S.Wongtrakoongate P.Kuhakarn C.Mahidol University2023-06-182023-06-182022-09-01Synlett Vol.33 No.14 (2022) , 1411-141809365214https://repository.li.mahidol.ac.th/handle/20.500.14594/84172A facile and convenient reaction of o-alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones, -keto esters, and -keto amides, under Br nsted basic conditions, has been developed. Diethyl malonate reacted smoothly with a collection of o-alkynylisocyanobenzenes to provide the corresponding 2-quinolin-2-yl malonates in excellent yields. Acetylacetone gave a mixture of quinolin-4-yl and quinolin-2-yl derivatives. Acetoacetate esters and acetoacetyl amide derivative initially gave 2-quinolin- 2-yl adducts that underwent partial deacetylation under the reaction conditions.ChemistryArticleSCOPUS10.1055/a-1784-25132-s2.0-8512732772814372096