Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

Ruangrat ChoommongkolRattana JongkolSamran PrabpaiPalangpon KongsaereePuttinan MeepowpanChiang Mai UniversityMahidol University2018-06-112018-06-112012-03-15Tetrahedron Asymmetry. Vol.23, No.5 (2012), 357-3631362511X095741662-s2.0-84860307253https://repository.li.mahidol.ac.th/handle/20.500.14594/13922Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC 50 values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved.Mahidol UniversityChemical EngineeringChemistrySynthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key stepsArticleSCOPUS10.1016/j.tetasy.2012.03.006