Supaporn SawadjoonPrasat KittakoopKanyawim KirtikaraVanicha VichaiMorakot TanticharoenYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-07-242018-07-242002-08-09Journal of Organic Chemistry. Vol.67, No.16 (2002), 5470-5475002232632-s2.0-0037047548https://repository.li.mahidol.ac.th/handle/20.500.14594/20123The first naturally occurring atropisomeric flavans, myristinins B (2), ] (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH2Cl2 extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture of 4 and 4a, exhibited antifungal activity against Candida albicans with IC50 values ranging from 5.9 to 8.8 μg/mL, and they selectively inhibited the enzyme cyclooxygenase-2 (COX-2).Mahidol UniversityChemistryArticleSCOPUS10.1021/jo020045d