C. ToskulkaoT. GlinsukonB. KongsuktrakoonS. SophasanW. ThamavitMahidol University2018-04-302018-04-301980-12-01Research Communications in Chemical Pathology and Pharmacology. Vol.30, No.3 (1980), 521-534003451642-s2.0-0019179003https://repository.li.mahidol.ac.th/handle/20.500.14594/11186The effect of various cytochalasins on intestinal glucose absorption in several animal species was investigated in vitro. Glucose absorption in mouse jejunum was highly inhibited (68.1%) by cytochalasin E (25.0 μg/ml) within 30-min incubation and less extent in rat (48.9%), hamster (34.1%), frog (28.1%), guinea pig (27.5%), rabbit (24.3%) and turtle jejunum (22.7%). Among cytochalasins A, B, C, D and E, cytochalasin E was a most potent derivative that could inhibit glucose absorption by up to 55.5% at a concentration of only 5.0 μg/ml in mouse jejunum and its effect may possibly be related to the formation of mini villi and the intracellular vacuoles in the intestinal absorptive cells.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS