Thamsiri P.Rukachaisirikul V.Phongpaichit S.Preedanon S.Sakayaroj J.Muanprasat C.Hadsadee S.Jungsuttiwong S.Mahidol University2024-11-042024-11-042024-01-01Natural Product Research (2024)14786419https://repository.li.mahidol.ac.th/handle/20.500.14594/101863Three new isochroman derivatives, penicitrisochromans A-C (1-3), together with 25 known polyketides were isolated from the marine-derived fungus Penicillium citrinum PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of 3 were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, ω-hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant Staphylococcus aureus with MIC values of 32, 16 and 4 µg/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against Candida albicans NCPF3153 and Cryptococcus neoformans ATCC90112 with the respective MIC values of 16 and 64 µg/mL.ChemistryBiochemistry, Genetics and Molecular BiologyAgricultural and Biological SciencesArticleSCOPUS10.1080/14786419.2024.24165152-s2.0-852072850411478642739428755