de Carvalho Nunes G.Wutthigate P.Simoneau J.Dancea A.Beltempo M.Renaud C.Altit G.Mahidol University2023-05-232023-05-232023-02-01Journal of Perinatology Vol.43 No.2 (2023) , 174-18007438346https://repository.li.mahidol.ac.th/handle/20.500.14594/82692Objective: Evaluate factors associated with significant pulmonary hypertension [PH] (≥2/3 systemic) and its impact on ventricular function at 36 weeks postmenstrual age (PMA). Study design: Retrospective cohort of infants born at <29 weeks who survived to their echocardiography screening for PH at 36 weeks PMA. Masked experts extracted conventional and speckle-tracking echocardiography [STE] data. Results: Of 387 infants, 222 were included and 24 (11%) categorized as significant PH. Significant PH was associated with a decrease in tricuspid annular plane systolic excursion (0.79 vs 0.87 cm, p = 0.03), right peak longitudinal strain [pLS] by STE (−19.6 vs −23.1%, p = 0.003) and left pLS (−25.0 vs −22.7%, p = 0.02). The association between biventricular altered function by STE and significant PH persisted after adjustment for potential confounders – LV-pLS (p = 0.007) and RV-pLS (p = 0.01). Conclusion: Our findings are suggestive that premature newborns with significant PH at 36 weeks PMA have a biventricular cardiac involvement to their pathophysiology.MedicineArticleSCOPUS10.1038/s41372-022-01497-02-s2.0-851370413601476554336008520