Nongporn HutadilokWitaya ThamavitE. Suchart UpathamPintip RuenwongsaMahidol University2018-10-122018-10-121983-01-01Molecular and Biochemical Parasitology. Vol.9, No.4 (1983), 289-295016668512-s2.0-0021013142https://repository.li.mahidol.ac.th/handle/20.500.14594/30441Infection of hamsters by the human liver fluke Opisthorchis viverrini elevated liver procollagen prolyl hydroxylase activity, reflecting increased collagen biosynthesis. The increase was proportional to the intensity of infection. However, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused a transient increase in serum aminotransferase levels and a small but persistent rise in serum alkaline phosphatase. The drug, however, did not cause changes in these enzyme activities in the uninfected hamsters. © 1983.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyArticleSCOPUS10.1016/0166-6851(83)90085-3