A. BourahlaC. MartinF. GimenezV. SinghasivanonP. AttanathA. SabchearonT. ChongsuphajaisiddhiR. FarinottiHopital Pitie SalpetriereUniversite Paris-Sud XIMahidol University2018-07-042018-07-041996-06-03European Journal of Clinical Pharmacology. Vol.50, No.3 (1996), 241-244003169702-s2.0-0029989825https://repository.li.mahidol.ac.th/handle/20.500.14594/17729Objective: the stereospecificity of mefloquine pharmacokinetics in children has been investigated. Patients: Twelve children aged 6 to 24 months were treated for uncomplicated falciparum malaria with a single oral dose of 25 mg · kg-1 racemic mefloquine in combination with sulfadoxine and pyrimethamine. Methods: concentrations of mefloquine enantiomers were determined using a coupled achiral-chiral chromatographic system. Pharmacokinetic parameters were calculated using model-independent analysis. Results: Maximum plasma concentrations, areas under the curve and apparent plasma elimination half-lives were higher for the (-) enantiomer than its antipode. In contrast, the apparent volume of distribution (V/f) and total clearance (Cl/f) values were higher for the (+) enantiomer. Conclusion: the stereoselectivity of mefloquine pharmacokinetics is similar to that observed in adults.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1007/s002280050100