Hoontrakul T.Leenanupunth C.Siantong M.Sirisreetreerux P.Phongkitkarn S.Kongchareonsombat W.Kijvikai K.Mahidol University2024-03-132024-03-132024-03-04Scientific reports Vol.14 No.1 (2024) , 5341https://repository.li.mahidol.ac.th/handle/20.500.14594/97554To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor nephrectomy at Ramathibodi Hospital, Bangkok, Thailand. The study spanned over a comprehensive 60-month monitoring period. Residual renal volume was determined through Computer Tomography. Patient characteristics, surgical techniques, donated kidney side, and estimated glomerular filtration rate (eGFR) were collected and analysed. In a multivariate analysis, a residual renal volume exceeding 50% of original volume is associated with an increased likelihood of developing CKD, with a hazard ratio (HR) of 1.675 (P < 0.05), and male gender has a hazard ratio (HR) of 4.013 (P < 0.001). Additionally, age is identified as a minor risk factor for developing CKD, with hazard ratio (HR) of 1.107 (P < 0.001). Higher residual renal volume, male gender, and older age were identified as independent risk factors for the development of CKD following open or laparoscopic donor nephrectomy during long-term follow-up.MultidisciplinaryArticleSCOPUS10.1038/s41598-024-55499-32-s2.0-851868475442045232238438514