K. BoonsirisethM. M. LattS. KiattavorncharoenV. PairuchvejN. WongsirichatMahidol UniversityInsein General Hospital2018-12-212019-03-142018-12-212019-03-142017-07-01International Journal of Oral and Maxillofacial Surgery. Vol.46, No.7 (2017), 899-90413990020090150272-s2.0-85015319348https://repository.li.mahidol.ac.th/handle/20.500.14594/42453© 2017 International Association of Oral and Maxillofacial Surgeons The objective of this study was to evaluate the effects of 8 mg dexamethasone injection into the pterygomandibular space on the postoperative sequelae of lower third molar surgery. A prospective, randomized, controlled, split-mouth study was designed involving 62 lower third molar extractions (31 patients). Prior to surgery, the study group received 2 ml of 4 mg/ml (8 mg) dexamethasone injection through the pterygomandibular space following local anaesthesia; the control group received 2 ml normal saline injection. Facial swelling, mouth opening, pain on a visual analogue scale (VAS), and the number of analgesics consumed were assessed. Descriptive statistics and the independent-samples t-test were used to compare the two groups at P < 0.05. There was a significant reduction in swelling on day 2 postoperative in the dexamethasone group. Mouth opening was also significantly greater on day 2 in the dexamethasone group. The VAS pain score was significantly lower on the day of the operation and first postoperative day in the dexamethasone group, but did not differ significantly between the groups on the other postoperative days. The injection of 8 mg dexamethasone into the pterygomandibular space was effective in reducing postoperative swelling, limited mouth opening, and pain following impacted lower third molar extraction.Mahidol UniversityDentistryArticleSCOPUS10.1016/j.ijom.2017.02.1266