Savita ChewchindaNantakarn LeakayaHitoshi SatoVilasinee Hirunpanich SatoShowa UniversityMahidol University2020-01-272020-01-272019-01-01Journal of Traditional and Complementary Medicine. (2019)222541102-s2.0-85074153611https://repository.li.mahidol.ac.th/handle/20.500.14594/52045© 2019 Center for Food and Biomolecules, National Taiwan University Background and aim: Maclura cochinchinensis (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated. Experimental procedure: This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice. Results: In both OGTT and the daily oral administration for 28 days in STZ-NA-induced type 2 diabetic mice models, the extract (1,000 mg/kg) significantly decreased fasting blood glucose. This hypoglycemic effect was explained by increased insulin levels and α-glucosidase inhibition (IC50:1.53 ± 0.03 μg/mL). Conclusion: This first study on the hypoglycemic activity of MC heartwood extract indicates that it could be a potential natural remedy for type 2 diabetes.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.jtcme.2019.10.004