Amaraporn WongrakpanichJiraphong SuksiriworapongSean M. GearyPhawanan SawangchanJanjira IntraUracha RuktanonchaiAliasger K. SalemUniversity of IowaThailand National Nanotechnology CenterMahidol UniversityAmway (Thailand) Ltd2022-08-042022-08-042021-01-01Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine. (2021), 291-3102-s2.0-85126047341https://repository.li.mahidol.ac.th/handle/20.500.14594/76312Mitochondria have become a promising target for prevention and treatment of various diseases such as Alzheimer’s disease, Parkinson’s disease, ischemia-reperfusion injury, diabetes, obesity, and especially cancer. As a result, recent research has been focused on targeting mitochondria. To impact on mitochondrial functions, drug molecules need to be able to selectively travel to mitochondria and overcome barriers such as the cell membrane and mitochondrial membrane. This can be enhanced through various delivery systems which include liposomes, polymeric particles, and inorganic particles. These delivery systems are often decorated with mitochondriotropic moieties such as triphenylphosphonium and dequalinium. Here, we provide an overview of the various nanoparticle- and microparticle-based strategies used to deliver drugs to mitochondria.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyBook ChapterSCOPUS10.1016/B978-0-323-85666-9.00013-9