Kulachart JangpatarapongsaPatchanee ChootongJetsumon SattabongkotKesinee ChotivanichJeeraphat SirichaisinthopSumalee TungpradabkulHajime HisaedaMarita Troye-BlombergLiwang CuiRachanee UdomsangpetchMahidol UniversityArmed Forces Research Institute of Medical Sciences, ThailandThailand Ministry of Public HealthKyushu UniversityDepartment of Molecular Biosciences, The Wenner-Gren InstitutePennsylvania State University2018-07-122018-07-122008-12-01European Journal of Immunology. Vol.38, No.10 (2008), 2697-270515214141001429802-s2.0-58149252417https://repository.li.mahidol.ac.th/handle/20.500.14594/19270Immunity induced by Plasmodium vivax infections leads to memory T-cell recruitment and activation during subsequent infections. Here, we investigated the role of regulatory T cells (Treg) in coordination with the host immune response during P. vivax infection. Our results showed a significant increase in the percentage of FOXP3+ Treg, IL-10-secreting Type I Treg (Tr1) and IL-10 levels in patients with acute P. vivax infection as compared with those found in either naïve or immune controls. The concurrent increase in the Treg population could also be reproduced in vitro using peripheral blood mononuclear cells from naïve controls stimulated with crude antigens extracted from P. vivax-infected red blood cells. Acute P. vivax infections were associated with a significant decrease in the numbers of DC, indicating a general immunosuppression during P. vivax infections. However, unlike P. falciparum infections, we found that the ratio of myeloid DC (MDC) to plasmacytoid DC (PDC) was significantly lower in acute P. vivax patients than that of naïve and immune controls. Moreover, the reduction in PDC may be partly responsible for the poor antibody responses during P. vivax infections. Taken together, these results suggest that P. vivax parasites interact with DC, which alters the MDC/PDC ratio that potentially leads to Treg activation and IL-10 release. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1002/eji.200838186