Napasawan ChumnanvejNatthapol SamakkanadManat PohmakotrVichai ReutrakulThaworn JaipetchDarunee SoorukramChutima KuhakarnMahidol University2018-11-092018-11-092014-01-01RSC Advances. Vol.4, No.104 (2014), 59726-59732204620692-s2.0-84912038846https://repository.li.mahidol.ac.th/handle/20.500.14594/33576© The Royal Society of Chemistry 2014. A novel OXONE® mediated direct difunctionalization of alkenes with NaNO<inf>2</inf> in aqueous acetonitrile for the synthesis of α-nitrooximes was developed. The α-nitrooximes were readily prepared in moderate to high yields at room temperature under mild reaction conditions. The present protocol offers an easy and environmentally benign approach to access various α-nitrooximes derived from styrene derivatives.Mahidol UniversityChemical EngineeringChemistryArticleSCOPUS10.1039/c4ra11703d