Assmus F.Mahidol University2023-06-182023-06-182022-03-01PLoS Neglected Tropical Diseases Vol.16 No.3 (2022)19352727https://repository.li.mahidol.ac.th/handle/20.500.14594/86061To accelerate the progress towards onchocerciasis elimination, a macrofilaricidal drug that kills the adult parasite is urgently needed. Emodepside has shown macrofilaricidal activity against a variety of nematodes and is currently under clinical development for the treatment of onchocerciasis. The aims of this study were i) to characterize the population pharmacokinetic properties of emodepside, ii) to link its exposure to adverse events in healthy volunteers, and iii) to propose an optimized dosing regimen for a planned phase II study in onchocerciasis patients.MedicineArticleSCOPUS10.1371/journal.pntd.00102192-s2.0-851264123291935273535271567