Poramate SongthammawatSirilak WangngaeKoki MatsumotoChuthamat DuangkamolSomsak RuchirawatPoonsakdi PloypradithChulabhorn Research InstituteThailand Ministry of EducationMahidol UniversityChulabhorn Royal Academy2019-08-232019-08-232018-05-04Journal of Organic Chemistry. Vol.83, No.9 (2018), 5225-524115206904002232632-s2.0-85046284982https://repository.li.mahidol.ac.th/handle/20.500.14594/45495© 2018 American Chemical Society. The cyclohexene moiety of the tricyclic 6,7-diaryl-tetrahydro-6H-benzo[c]chromene core of palodesangrens could be assembled in a biomimetic and step-economical fashion by the Diels-Alder reaction between the electron-rich (E)-1,3-butadienylarenes as the diene and the electron-deficient chalcones as the dienophile. During the reduction of ketone to the corresponding alcohol by LiAlH4, the mixture of endo and exo isomers underwent a novel diastereoconvergent LiAlH4-mediated isomerization to install the desired stereochemistry at C10a. Subsequent pyran ring closure under acidic conditions installed the stereochemistry at the remaining C6. Overall, the tricyclic core of palodesangrens could be prepared in three steps and up to 38% yield.Mahidol UniversityChemistryArticleSCOPUS10.1021/acs.joc.8b00668