Chavi YenjaiSomkrit SripontanPrachack SriprajunPrasat KittakoopAmnuay JintasirikulMorakot TanticharoenYodhathai ThebtaranonthKhon Kaen UniversityJunior Science Talent ProjectThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-09-072018-09-072000-05-13Planta Medica. Vol.66, No.3 (2000), 277-279003209432-s2.0-0034107602https://repository.li.mahidol.ac.th/handle/123456789/25798Activity guided fractionation of extracts from Clausena harmandiana have led to the identification of four known compounds, heptaphylline (1), clausine K (2), dentatin (5), and clausarin (6). All these compounds, except clausine K (2), exhibited antiplasmodial activity against Plasmodium falciporum. While the new dimethylated derivative 4, derived from 2, showed no antiplasmodial activity, the monomethylated product 3 (clausine H) exhibited activity comparable to that observed for compounds 1 and 5.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-2000-8558