Orasa SuthienkulMasanori IshibashiTetsuya IidaNujjaree NettipSuvanee SupavejBoonchuay EampokalapMasanao MakinoTakeshi HondaMahidol UniversityBamrasnaradura Infectious Disease InstituteOsaka UniversityNational Sanatorium Oku-Komyoen2018-07-042018-07-041995-01-01Journal of Infectious Diseases. Vol.172, No.5 (1995), 1405-140815376613002218992-s2.0-0028784426https://repository.li.mahidol.ac.th/handle/20.500.14594/17328A total of 489 Vibrio parahaemolyticus isolates from patients in Thailand with diarrhea was examined for the presence of thermostable direct hemolysin (TDH) and TDH-related hemolysin genes (tdh and trh, respectively), their serovars, TDH production, and urease activity. Of the strains, 81% were positive only for the tdh gene, 6% for bothtrh and tdh genes, and 2% for the trh gene only. Thirty-seven (8%) of the 489 isolates were positive for urease production. Of special interest, all urease-positive strains possessed the trh gene, and conversely, urease-negative strains lacked the gene, indicating that urease production by V. parahaemolyticus strains strongly correlates with the possession of the trh gene. Thus, the urease-positive phenotype of V. parahaemolyticus can be considered an indication of virulent (trh-possessing) V. parahaemolyticus strains in clinical diagnosis. © 1995 The University of Chicago Press.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1093/infdis/172.5.1405