Ruengrit SappapanDamrong SommitNattaya NgamrojanavanichSomchai PengpreechaSuthep WiyakruttaNongluksna SriubolmasKhanitha PudhomChulalongkorn UniversityMahanakorn University of TechnologyMahidol University2018-07-122018-07-122008-09-01Journal of Natural Products. Vol.71, No.9 (2008), 1657-1659016338642-s2.0-54149106109https://repository.li.mahidol.ac.th/handle/20.500.14594/18870A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC 50 values of 0.68 and 7.70 μM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested. © 2008 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np8004024