N. J. WhiteR. E. PhillipsS. LooareesuwanP. ChanthavanichD. A. WarrellMahidol UniversityNuffield Department of Clinical Medicine2018-06-142018-06-141988-07-09The Lancet. Vol.332, No.8602 (1988), 64-66014067362-s2.0-0023905618https://repository.li.mahidol.ac.th/handle/20.500.14594/1561148 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3·5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12·5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria. © 1988.Mahidol UniversityMedicineArticleSCOPUS10.1016/S0140-6736(88)90002-5