Chakapong IntaraudomSutichai NitthithanasilpPranee RachtaweeTanapong BoonruangprapaSamran PrabpaiPalangpon KongsaereePattama PittayakhajonwutThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-11-232018-11-232015-12-01Phytochemistry. Vol.120, (2015), 19-27003194222-s2.0-84948181679https://repository.li.mahidol.ac.th/handle/20.500.14594/35064© 2015 Elsevier Ltd. All rights reserved. Ten compounds including nine phenalenone derivatives (five bipolarides and four bipolarols) and a sesterterpene acid (bipolarenic acid), were isolated from a marine isolated of the fungus Lophiostoma bipolare (BCC25910), along with the known compounds, (-)-scleroderolide, (-)-sclerodin, and oxasetin. Chemical structures were elucidated based on NMR spectroscopic data and HRESIMS analysis. In addition, the absolute configurations of the phenalenones were resolved using specific rotations and chemical means, while the relative configuration of bipolarenic acid was confirmed by X-ray crystallographic analysis. The compounds were evaluated for biological activity against the Plasmodium falciparum K-1 strain, Candida albicans, and Bacillus cereus, and for cytotoxicity against both cancerous and non-cancerous cells.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/j.phytochem.2015.11.003