Pathompong P.Pfütze S.Surup F.Boonpratuang T.Choeyklin R.Matasyoh J.C.Decock C.Stadler M.Boonchird C.Mahidol University2023-06-182023-06-182022-09-01Molecules Vol.27 No.18 (2022)https://repository.li.mahidol.ac.th/handle/20.500.14594/84162Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities.ChemistryArticleSCOPUS10.3390/molecules271859682-s2.0-8513894761814203049