N. ChierakulD. KlomsawatS. ChulavatnatolB. ChindavijakMahidol University2018-09-072018-09-072001-05-14International Journal of Tuberculosis and Lung Disease. Vol.5, No.3 (2001), 278-282102737192-s2.0-0035042657https://repository.li.mahidol.ac.th/handle/20.500.14594/26786OBJECTIVE: To determine the lung epithelial lining fluid (ELF) and serum levels of ofloxacin in drug-resistant tuberculosis patients during treatment. DESIGN: Ten drug-resistant tuberculosis patients treated with ofloxacin containing regimens for at least 2 weeks were enrolled in the study. Subjects ingested ofloxacin 10 mg/kg and other anti-tuberculosis agents after overnight fasting. RESULTS: Serum and bronchoalveolar lavage fluid were collected at 4 hours after treatment and assayed by high performance liquid chromatography. The mean concentrations of ofloxacin in serum and ELF were 5.889 ± 1.096 and 16.583 ± 8.697 mg/L, respectively. The mean ratio of ELF-to-serum ofloxacin concentration was 2.825 ± 1.275. CONCLUSION: Ofloxacin can penetrate well into the intra-alveolar fluid of patients treated for drug-resistant tuberculosis. The lung ELF concentrations were consistently higher than the minimal inhibitory concentrations of Mycobacterium tuberculosis as determined in vitro.Mahidol UniversityMedicineArticleSCOPUS