Crossed immunoelectrophoresis for the detection of split products of the third complement component in dengue hemorrhagic fever. II. In vitro activation by dengue viral antigen

V. ChurdboonchartN. BhamarapravatiS. YoksanMahidol University2018-10-122018-10-121984-01-01American Journal of Tropical Medicine and Hygiene. Vol.33, No.6 (1984), 1239-1247000296372-s2.0-0021716314https://repository.li.mahidol.ac.th/handle/20.500.14594/30613The ability of dengue viral antigen(s) from different sources, and preformed antigen-antibody complexes, to activate the third component of human complement (C3) in vitro was demonstrated by using split products of human C3. Dengue type 2 viral antigen(s) from suckling mouse brain and from infected monocytes activated C3 via the alternative pathway, while preformed soluble dengue-2 antibody complex activated mainly the classical pathway. The implications of this finding for the pathogenesis of dengue hemorrhagic fever are discussed.Mahidol UniversityImmunology and MicrobiologyMedicineCrossed immunoelectrophoresis for the detection of split products of the third complement component in dengue hemorrhagic fever. II. In vitro activation by dengue viral antigenArticleSCOPUS10.4269/ajtmh.1984.33.1239