Chutima JiarpinitnunLaura L. KiesslingUniversity of Wisconsin MadisonMahidol University2018-09-242018-09-242010-07-07Journal of the American Chemical Society. Vol.132, No.26 (2010), 8844-884515205126000278632-s2.0-77954301795https://repository.li.mahidol.ac.th/handle/123456789/28671Polyethylene glycol (PEG) is widely used, and many biologically active molecules are modified with oligoethylene glycol substituents to enhance their half-lives in circulation. The pervasive use of PEG substituents is partly due to their presumed inertness. Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine- phenylalanine (fMLF) to activate signal transduction through FPR, a transmembrane G-protein-coupled receptor. © 2010 American Chemical Society.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemical EngineeringChemistryMedicineArticleSCOPUS10.1021/ja102640c