Comparative accuracy of the InBios scrub typhus detect IgM rapid test for the detection of IgM antibodies by using conventional serology

Hugh W.F. KingstonStuart D. BlacksellAmpai TanganuchitcharnchaiAchara LaongnualpanichBuddha BasnyatNicholas P.J. DayDaniel H. ParisMahidol UniversityMenzies School of Health ResearchChurchill HospitalChiangrai Prachanukhru HospitalOxford University Clinical Research Unit2018-11-232018-11-232015-10-01Clinical and Vaccine Immunology. Vol.22, No.10 (2015), 1130-11321556679X155668112-s2.0-84943262734https://repository.li.mahidol.ac.th/handle/20.500.14594/35377Copyright © 2015, American Society for Microbiology. All Rights Reserved. This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineComparative accuracy of the InBios scrub typhus detect IgM rapid test for the detection of IgM antibodies by using conventional serologyArticleSCOPUS10.1128/CVI.00390-15