Ramishvili T.Khandaker R.Himes C.Beckham D.Schwarz J.N.Rojanapithayakorn N.Freda J.Strätz D.Suleiman A.Tufail B.Zmily O.M.Droege L.Alpert J.E.Alexander J.Masoumi S.Wongtangman K.Rego S.A.Fassbender P.Eikermann M.Mahidol University2026-04-292026-04-292026-06-01Journal of Clinical Anesthesia Vol.112 (2026)09528180https://repository.li.mahidol.ac.th/handle/123456789/116433Background Diagnosed anxiety disorder is a predictor of same-day case cancellations. Many patients experience significant preoperative anxiety without a formal diagnosis. We investigated whether high preoperative anxiety independently predicts same-day case cancellations beyond established risk factors. Methods This prospective study was conducted at Montefiore Medical Center between April 2023 and January 2025. Anxiety was assessed one day preoperatively using a self-reported Numeric Rating Scale (NRS:0–10). High anxiety was defined as NRS ≥5. The primary outcome was same-day case cancellation. We used modified Poisson and logistic regressions to examine associations between exposure and outcome, adjusting for known predictors of same-day case cancellation. Results The final cohort included 6469 cases, of which 1248 (19.3%) reported high preoperative anxiety whereas only 9.5% of them had a documented anxiety diagnosis. The most frequently reported concerns were complications in surgery (1147 (17.7%)), postoperative complications (811 (12.5%)), and pain (682 (10.5%)). Same-day case cancellation rates were 6.0% (312/5221) for patients with low anxiety and 7.7% (96/1248) for those with high anxiety (risk difference 1.7% (95%CI (confidence interval): 0.1% –3.3%), p = 0.025). The attributable risk fraction of high anxiety for same-day case cancellation amounted to 22.1%. High anxiety was associated with an increased risk of case cancellation (adjusted risk ratio 1.29; 95%CI: 1.04–1.62; p = 0.023). An increase in each NRS anxiety score (0−10) was dose-dependently associated with added risk of case cancellation (adjusted odds ratio 1.04; 95%CI: 1.01–1.08; p = 0.019). Conclusions A significant level of preoperative anxiety occurs in one out of 5 patients and is an independent predictor of surgical case cancellations. One-fifth of same-day case cancellations in patients can be attributed to preoperative anxiety, which may potentially be addressed by a preoperative intervention.MedicineArticleSCOPUS10.1016/j.jclinane.2026.1122052-s2.0-10503586953718734529