Sutanun DoungsoongnuenApilak WorachartcheewanRatchanok PingaewThummaruk SuksrichavalitSupaluk PrachayasittikulSomsak RuchirawatVirapong PrachayasittikulSrinakharinwirot UniversityMahidol UniversityChulabhorn Research Institute2018-05-032018-05-032011-12-01EXCLI Journal. Vol.10, (2011), 155-161161121562-s2.0-84855815989https://repository.li.mahidol.ac.th/handle/20.500.14594/11231In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO 2 , OCH 3 , CH 3 , Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50% inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO 2 ) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsArticleSCOPUS