Suthat FucharoenPranee WinichagoonRaewadee WisedpanichkijBusara Sae-NgowRungrat SriphanichWarangkana OncoungWanna MuangsapayaJew ChowthawornSujin KanokpongsakdiAhnond BunyaratvejAnong PiankijagumChris DewaeleMahidol UniversityBio-Rad LaboratoriesThe Institute of Science and Technology for Research and Development, Mahidol University2018-07-042018-07-041998-04-29Clinical Chemistry. Vol.44, No.4 (1998), 740-748000991472-s2.0-14444283108https://repository.li.mahidol.ac.th/handle/20.500.14594/18303The conventional approach to qualitative and quantitative analyses of hemoglobin (Hb) molecules for the diagnoses of hemoglobinopathies requires a combination of tests. We used an automated HPLC (VARIANT(TM)) system to study α-thalassemia and β-thalassemia syndromes in Thailand. The beta-thalassemia short program is applicable to the diagnosis of α-thalassemia and β- thalassemia disorders, including Hb H, EA Bart's disease, and EF Bart's disease, in adults, newborns, and fetuses. The system cannot quantify accurately certain Hb molecules, such as Hb H and Hb Bart's. The alpha- thalassemia short program was therefore developed and used to quantify Hb Bart's to detect α-thalassemia genotypes in cord blood. This automated HPLC system is an alternative approach to the diagnosis of complicated thalassemia syndromes in Thailand and Southeast Asia.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS