Atthaporn BoongirdJiraporn LaothamatasNoppadol LarbcharoensubSuchart PhudhichareonratMahidol UniversityDepartment of Radiology andPrasat Neurological Institute2018-09-132018-09-132009-10-01Neuropathology. Vol.29, No.5 (2009), 591-59614401789091965442-s2.0-70349319729https://repository.li.mahidol.ac.th/handle/20.500.14594/27908A case of malignant craniopharyngioma in a 46-year-old woman presenting clinically with visual disturbance and bifrontal headache is reported. Histopathologic examination of the suprasellar mass showed a lesion characterized by nests of epithelial cells with a basaloid appearance, round-to-oval nuclei, moderate pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio and high mitotic activity. Immunohistochemically, the tumor cells were positive for Ki-67 (44.3%), p53 (98%), and p63 (100%), but negative for estrogen and progesterone receptors. Clinical and pathologic features with a brief review of the relevant literature for malignant craniopharyngioma as a novel member of tumors of the suprasellar region, is discussed. © 2008 Japanese Society of Neuropathology.Mahidol UniversityMedicineArticleSCOPUS10.1111/j.1440-1789.2008.00986.x