Chiara RobbaSabrine N.T. HemmesAry Serpa NetoThomas BluthJaume CanetMichael HiesmayrM. Wiersma HollmannGary H. MillsMarcos F. Vidal MeloChristian PutensenSamir JaberWerner SchmidPaolo SevergniniHermann WriggeDenise BattagliniLorenzo BallMarcelo Gama De AbreuMarcus J. SchultzPaolo PelosiWolfgang KroellHelfried MetzlerGerd StruberThomas WegscheiderHans GombotzMichael HiesmayrWerner SchmidBernhard UrbanekDavid KahnMona MomeniAudrey PospiechFernande LoisPatrice ForgetIrina GrosuJan PoelaertVeerle Van MosseveldeMarie Claire Van MalderenDimitri DylstJeroen Van MelkebeekMaud BeranStefan De HertLuc De BaerdemaekerBjorn HeyseJurgen Van LimmenPiet WyffelsTom JacobsNathalie RoelsAnn De BruyneStijn Van De VeldeBrigitte LevaSandrine DamsterBenoit PlichonMarina Juros-ZovkoDejana Djonoviċ-OmanoviċSelma PernarJosip ZunicPetar MiskovicAntonio ZilicSlavica KvolikDubravka IvicDarija Azenic-VenzeraSonja SkiljicHrvoje VinkovicIvana OputricKazimir JuricicVedran FrkovicJasminka KopicIvan MirkovicNenad KaranovicMladen CarevNatasa DropulicJadranka Pavicic SaricGorjana ErcegMatea Bogdanovic DvorscakBranka Mazul-SunkoAnna Marija PavicicTanja GoranovicBranka MaldiniTomislav RadocajZeljka GavranovicInga Mladic-BatinicaMirna SehovicPetr StouracHana HarazimOlga SmekalovaMartina KosinovaTomas KolacekKamil HudacekMichal DrabJan BrujevicKaterina VitkovaKaterina JirmanovaIvana VolfovaPaula DzurnakovaKatarina LiskovaRadovan DudasRadek FilipskySamir El KafrawyHisham Hosny AbdelwahabTarek MetwallyAhmed Abdel-RazekOspedale Policlinico San MartinoCHU MontpellierUniversitäts-Klinikum Bonn und Medizinische FakultätMassachusetts General HospitalDresden University Faculty of Medicine and University Hospital Carl Gustav CarusUniversità degli Studi di GenovaHospital Israelita Albert EinsteinMahidol UniversityHospital Universitari de BellvitgeMedizinische Universitat WienUniversität LeipzigUniversità degli Studi dell'InsubriaUniversity of SheffieldAmsterdam UMC - University of Amsterdam2020-05-052020-05-052020-04-02BMC Anesthesiology. Vol.20, No.1 (2020)147122532-s2.0-85082895096https://repository.li.mahidol.ac.th/handle/20.500.14594/54608© 2020 The Author(s). Background: Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods: Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into groups based on the type of surgery (brain and spine), the occurrence of PPCs and the assess respiratory risk in surgical patients in Catalonia (ARISCAT) score risk for PPCs. Results: Seven hundred eighty-four patients were included in the analysis; 408 patients (52%) underwent spine surgery and 376 patients (48%) brain surgery. Median tidal volume (VT) was 8 ml [Interquartile Range, IQR = 7.3-9] per predicted body weight; median positive end-expiratory pressure (PEEP) was 5 [3 to 5] cmH20. Planned recruitment manoeuvres were used in the 6.9% of patients. No differences in ventilator settings were found among the sub-groups. PPCs occurred in 81 patients (10.3%). Duration of anaesthesia (odds ratio, 1.295 [95% confidence interval 1.067 to 1.572]; p = 0.009) and higher age for the brain group (odds ratio, 0.000 [0.000 to 0.189]; p = 0.031), but not intraoperative ventilator settings were independently associated with development of PPCs. Conclusions: Neurosurgical patients are ventilated with low VT and low PEEP, while recruitment manoeuvres are seldom applied. Intraoperative ventilator settings are not associated with PPCs.Mahidol UniversityMedicineArticleSCOPUS10.1186/s12871-020-00988-x