Mingkwan PanyasrivanitAtefeh KhakpoorNitwara WikanDuncan R. SmithMahidol University2018-09-132018-09-132009-04-01Autophagy. Vol.5, No.3 (2009), 434-43515548635155486272-s2.0-65249100786https://repository.li.mahidol.ac.th/handle/20.500.14594/27249Amphisomes are preautolysosomal vacuoles formed upon the fusion of autophagosomes with endosomes, and as such represent a critical meeting point between endocytic and autophagic pathways. Dengue virus enters into susceptible cells by clathrin-mediated endocytosis, and colocalization of dengue markers with markers of both autophagic and endosomal vesicles demonstrates that amphi-somes are a site of dengue virus replication and translation. This work links for the first time the processes of dengue virus entry and translation/replication, and allows for interpretation of the early part of the dengue virus life cycle in terms of a continual association with membranes of an endosomal-autophagosomal lineage. © 2009 Landes Bioscience.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.4161/auto.5.3.7925