Supannee PhothongkamSirirat ChancharuneeAngkana SaovapakhiranUthai WichaiManat PohmakotrChiang Mai UniversityNaresuan UniversityMahidol University2018-06-112018-06-112012-12-15Bioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601146434050960894X2-s2.0-84870236110https://repository.li.mahidol.ac.th/handle/123456789/13546In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dime rs 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.bmcl.2012.10.020