Rojsanga PiyanuchMugdha SukhthankarGritsanapan WandeeSeung Joon BaekUniversity of Tennessee College of Veterinary MedicineMahidol University2018-08-242018-08-242007-12-18Cancer Letters. Vol.258, No.2 (2007), 230-240030438352-s2.0-36148962372https://repository.li.mahidol.ac.th/handle/20.500.14594/24058Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis. © 2007 Elsevier Ireland Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/j.canlet.2007.09.007