Soontorn ChooprayoonChutima KuhakarnPatoomratana TuchindaVichai ReutrakulManat PohmakotrMahidol University2018-05-032018-05-032011-01-21Organic and Biomolecular Chemistry. Vol.9, No.2 (2011), 531-537147705202-s2.0-78650732491https://repository.li.mahidol.ac.th/handle/20.500.14594/11603A concise asymmetric synthesis of (+)-swainsonine (ent-1) is described starting from 2, which was readily prepared from commercially available l-glutamic acid. The method features installation of the indolizidine ring via an intramolecular cyclisation of α-sulfinyl carbanion as a key step. (+)-Swainsonine was obtained in 11.8% overall yield in 10 steps. © 2011 The Royal Society of Chemistry.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c0ob00388c