Karan PaisooksantivatanaChanidapa Iamsa-artฺBenjawan RungsimapornSomjai KanjanapongkulSurapon WorapongpaiboonSamart Pakakasamaการันต์ ไพสุขศานติวัฒนาชนิดาภา เอี่ยมสอาดเบญจวรรณ รังสิมาภรณ์สมใจ กาญจนาพงศ์กุลสุรพล วรพงศ์ไพบูลย์สามารถ ภคกษมาMahidol University. Faculty of Medicine Ramathibodi Hospital. Department of PathologyQueen Sirikit National Institute of Child Health. Department of PediatricsSamitivej Hospital. Pathology UnitMahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Pediatrics2022-10-102022-10-102022-10-102010Ramathibodi Medical Journal. Vol. 33, No. 3 (Jul-Sep 2010), 200-2080125-3611 (Print)2651-0561 (Online)https://repository.li.mahidol.ac.th/handle/20.500.14594/79868Background: ZAP-70 expression was found in normal human B cell precursors and B lymphoproliferative disorders. Since the level of ZAP-70 expression is prognositic in chronic lymphocytic leukemia, a similar role may be demonstrable in other B-lineage malignancies. The present study investigates the expression of ZAP-70 in B-lineage acute lymphoblastic leukemia and its prognostic significance. Methods: Thirty-three bone marrow and blood samples were obtained from children newly diagnosed with B-lineage ALL. ZAP-70 was determined using flow cytometry. Correlation between expression of ZAP-70 and clinicobiological presenting features (age, sex, white blood cells) and cytogenetics was performed. Results: ZAP-70 was expressed in all cases with a wide variation (0.11 - 87.68%). There is no correlation between ZAP-70 expression level and clinicobiological presenting features also the cytogenetics abnormalities was found. Aberrantly high expression of ZAP-70 was found in three cases, two of which had aberrant CD13 and CD33 co-expression. Conclusions: Aberrantly high expression of ZAP-70 might be associated with certain subgroup (CD13 and CD33 coexpression) of B-lineage ALL.engMahidol UniversityZAP-70Acute lymphocytic leukemiaOriginal ArticleDepartment of Pathology Faculty of Medicine Ramathibodi Hospital Mahidol UniversityDepartment of Pediatrics Queen Sirikit National Institute of Child HealthSamitivej Hospital. Pathology UnitDepartment of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University