P. Bhanchet-IsarangkuraMahidol University2018-06-012018-06-011979-12-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.10, No.3 (1979), 350-352003836192-s2.0-0018568789https://repository.li.mahidol.ac.th/handle/20.500.14594/13218Acquired prothrombin complex deficiency (APCD) in infants of 1-2 months of age was described in 1966, but the precise pathogenesis has remained unclear. The authors feel that APCD is the result of a vitamin K deficiency due to several factors: 1) most of the afflicted (98%) have been breast fed, and human milk is low in vitamin K content; 2) APCD commonly occurs at an age before additional food has been added to the infant diet; and 3) the syndrome occurs in areas where vitamin K prophylaxis is not given to neonates. The authors do not discourage breast feeding, but do encourage vitamin K prophylaxis. (Van Slyck - Detroit, Mich.)Mahidol UniversityMedicineArticleSCOPUS