The S. MoeSuppisak ChaturonrutsameeSamreang BunteangChutima KuhakarnSamran PrabpaiPanida SurawatanawongArthit ChairoungduaKanoknetr SuksenRadeekorn AkkarawongsapatJitra LimthongkulChanita NapaswadNarong NuntasaenVichai ReutrakulThailand Ministry of Natural Resources and EnvironmentMahidol UniversityLtd.Ministry of Education2022-08-042022-08-042021-02-26Journal of Natural Products. Vol.84, No.2 (2021), 518-52615206025016338642-s2.0-85099089779https://repository.li.mahidol.ac.th/handle/20.500.14594/76275Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/acs.jnatprod.0c00629