S. ThanakunS. Pornprasertsuk-DamrongsriY. IzumiMahidol UniversityTokyo Medical and Dental University2018-12-212019-03-142018-12-212019-03-142017-10-01Oral Diseases. Vol.23, No.7 (2017), 956-965160108251354523X2-s2.0-85019188721https://repository.li.mahidol.ac.th/handle/20.500.14594/42405© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved Objectives: The association between body mass index (BMI) and oral diseases was investigated, and levels of obesity-related inflammatory mediators were evaluated. Subjects and Methods: Participants (n = 160) were clinically and radiographically examined for oral diseases. Blood profiles were recorded. Levels of adiponectin, leptin, and C-reactive protein (CRP) were measured. Results: One hundred and thirteen (70.6%) participants had overweight or obese status (BMI ≥ 23.0 kg/m2). Sum of dental diseases and severe periodontitis were higher in overweight or obese individuals than in normal-weight participants (p =.037 and p =.002, respectively). A significant difference in oral mucosal disorders between normal weight and overweight or obesity was not found. Plasma leukocyte counts, liver enzymes, leptin, and CRP levels were increased while adiponectin levels were decreased in individuals with BMI≥23.0 kg/m2compared with normal-weight participants. After adjusting for age, sex, fasting plasma glucose level, smoking, and exercise, obesity was associated with sum of dental diseases (ß = 0.239, p =.013), severe periodontitis (OR=4.52; 95% CI 1.37, 14.95, p =.013), adiponectin (ß = –0.359, p <.001), leptin (ß = 0.630, p <.001), and CRP levels (OR=12.66; 95% CI 3.07, 52.21, p <.001). Conclusion: Overweight or obese Thai people were related to an increase in inflammatory dental and periodontal diseases with an altered health profile and plasma inflammatory mediators.Mahidol UniversityDentistryArticleSCOPUS10.1111/odi.12679