Apichati VichayanratBien J. MatawaranAris WibudiHossain S. FerdousAzizul Hasan AamirSanjay K. AggarwalShailendra BajpaiMahidol UniversityUniversity of Santo Tomas HospitalGatot Subroto Army HospitalBIRDEM HospitalDepartment of Diabetes Endocrinology and Metabolic Diseases2018-10-192018-10-192013-09-01Journal of Diabetes. Vol.5, No.3 (2013), 309-31817530407175303932-s2.0-84881549550https://repository.li.mahidol.ac.th/handle/20.500.14594/32185Background: To assess baseline characteristics, glycemic control, and treatment with oral antidiabetic drugs (OAD) in type 2 diabetes mellitus (T2DM) patients. Methods: This multinational, observational study recruited patients ≥21 years of age who were newly diagnosed and/or treated with OAD monotherapy for <6 months but were inadequately controlled. In cross-sectional phase, data on demographics, medical history, diabetic complications and comorbidities, OAD treatment, glycosylated hemoglobin (HbA1c), and fasting blood glucose (FBG) were collected. In longitudinal phase evaluating 6-month follow-up of sulfonylurea (SU)-treated patients, additional data on reasons for not achieving HbA1c targets were collected. Results: Of 1487 patients (mean [±SD] age 52.0±11.6 years; 46.7% men; mean BMI 25.8±4.4kg/m2) recruited, 75.9% were newly diagnosed, 73.3% had central obesity, 43.8% had hypertension, and 60.5% had dyslipidemia. The mean HbA1c was 9.8±2.4%, and the mean FBG was 11.3±4.3mmol/L. At T0(baseline) and T6(month 6 visit), 99.8% (n=1066) and 97.1% (n=830) patients received SU, respectively. There was decrease from T0to T6in mean HbA1c (10.2% vs 7.3%, respectively; P<0.0001) and mean FBG (12.0 vs 7.6 mmol/L, respectively; P<0.0001). Number of patients with HbA1c <7% increased from T0(4.5%) to T6(46.8%). Reasons for not achieving target HbA1c included poor diabetes education (50.7%), non-compliance to OADs (21.4%), and fear of hypoglycemia (19.7%). Conclusion: Marked reductions in HbA1c and FBG are achievable in T2DM patients managed with OADs. However, patient education and compliance are important for achieving and maintaining treatment targets. © 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine.Mahidol UniversityMedicineArticleSCOPUS10.1111/1753-0407.12038