Jeffrey I. WeitzSylvia HaasWalter AgenoSamuel Z. GoldhaberAlexander G.G. TurpieShinya GotoPantep AngchaisuksiriJørn Dalsgaard NielsenGloria KayaniAlfredo E. FarjatSebastian SchellongHenri BounameauxLorenzo G. MantovaniPaolo PrandoniAjay K. KakkarAb LoualidiAbdurrahim ColakAbraham BezuidenhoutAbu Abdool-CarrimAddala AzeddineAdriaan BeyersAdriaan DeesAhmed MohamedAhmet AksoyAkihiko AbikoAkinori WatanabeAlan KrichellAlberto Alfredo FernandezAlberto TosettoAlexey KhotuntsovAlisha OropalloAlison SlocombeAllan KellyAmanda ClarkAmr GadAmy ArouniAndor SchmidtAndrea BerniAndres Javier KleibanAndrew MachowskiAndrey KazakovAngel GalvezAnn LockmanAnna FalangaAnoop ChauhanAntoni Riera-MestreAntonino MazzoneArmando D’AngeloArtur HerdyAtsushi KatoAyman Abd Elhamid Ebrahim Mahmoud SalemAzlan HusinBarbara ErdelyiBarry JacobsonBeatrice Amann-VestiBektas BattalogluBenedicte WilsonBenilde CosmiBergmann Jean FrancoisBerremeli ToufekBeverley HuntBhavesh NathaBisher MustafaBonnie Chi Shan KhoBoulon CarineBrian ZidelBrisot DominiqueBrousse ChristopheBruno TrimarcoCanhua LuoCarlos Alberto CuneoCarlos Jerjes Sanchez DiazCarsten SchwenckeCas CaderCelal YavuzCesar Javier ZaidmanCharles LunnChau Chung WuCheng Hock TohChern En ChiangChevrier ElisaChien Hsun HsiaChien Lung HuangChi Hang Kevin KwokChih Cheng WuChi Hung HuangChris WardChristian OpitzChristina Jeanneret-GrisChung Yin HaChun Yao HuangClaude Luyeye BidiClifford SmithCornelia BrauerCorrado LodigianiCouturaud FrancisCynthia WuDaniel StaubDaniel TheodoroDaniela PoliThrombosis & Atherosclerosis Research InstituteIRCCS MultimedicaMcMaster UniversityTokai University School of MedicineUniversity College LondonTechnical University of MunichFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityCopenhagen University HospitalThrombosis Research InstituteUniversity of Milano - BicoccaHôpitaux universitaires de GenèveUniversità degli Studi dell'InsubriaHarvard Medical SchoolMunicipal Hospital DresdenArianna Foundation on Anticoagulation2020-08-252020-08-252020-01-01Journal of Thrombosis and Thrombolysis. (2020)1573742X092953052-s2.0-85086853155https://repository.li.mahidol.ac.th/handle/20.500.14594/58337© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Venous thromboembolism (VTE) is common in cancer patients and is an important cause of morbidity and mortality. The Global Anticoagulant Registry in the FIELD (GARFIELD)–VTE (ClinicalTrials.gov: NCT02155491) is a prospective, observational study of 10,684 patients with objectively diagnosed VTE from 415 sites in 28 countries. We compared baseline characteristics, VTE treatment patterns, and 1-year outcomes (mortality, recurrent VTE and major bleeding) in 1075 patients with active cancer, 674 patients with a history of cancer, and 8935 patients without cancer. Patients with active cancer and history of cancer were older than cancer-free patients, with median ages of 64.8, 68.9, and 58.4 years, respectively. The most common sites of active cancer were lung (14.5%), colorectal (11.0%), breast (10.6%), and gynaecological (10.3%). Active cancer patients had a higher incidence of upper limb and vena cava thrombosis than cancer-free patients (9.0% vs 4.8% and 5.1% vs 1.4%, respectively), and were more likely to receive parenteral anticoagulation as monotherapy than cancer-free patients (57.8% vs 12.1%), and less likely to receive DOACs (14.2% vs 50.6%). Rates of death, recurrent VTE, and major bleeding were higher in active cancer patients than in cancer-free patients, with hazard ratios (95% confidence intervals) of 14.2 (12.1–16.6), 1.6 (1.2–2.0) and 3.8 (2.9–5.0), respectively. VTE was the second most common cause of death in patients with active cancer or history of cancer. In patients with VTE, those with active cancer are at higher risk of death, recurrence, and major bleeding than those without cancer.Mahidol UniversityMedicineArticleSCOPUS10.1007/s11239-020-02180-x