Taweekiat DujneungkunakornAsda VibhagoolWasun ChantratitaJiraporn LaothamatasSomnuek SungkanuparphWantanit PairojChutatip SrichunrusamiTeeratorn PulkesMahidol University2018-07-242018-07-242002-10-01Journal of the Medical Association of Thailand. Vol.85, No.10 (2002), 1139-1144012522082-s2.0-0036823445https://repository.li.mahidol.ac.th/handle/20.500.14594/20349Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.Mahidol UniversityMedicineArticleSCOPUS