Kamonrat PhopinNujarin SinthupoomLertyot TreeratanapiboonSarun KunwittayaSupaluk PrachayasittikulSomsak RuchirawatVirapong PrachayasittikulMahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology2016-04-202017-06-202016-04-202017-06-202015-12EXCLI Journal. Vol.15, 2016, 144-152https://repository.li.mahidol.ac.th/handle/20.500.14594/21358-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.Open Access articleArticle